Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment
option for patients suffering from chemotherapy-refractory or relapsed hematological …

X-linked agammaglobulinemia (XLA) has been associated with a broad range of infections,
but enteroviral disease represents one of the most damaging infections. The risk of …

Newborn screening for severe primary immunodeficiencies (PID), characterized by T and/or
B cell lymphopenia, was carried out in a pilot program in the Stockholm County, Sweden …

Over the past 15 years, SCT has emerged as a promising treatment option for patients with
severe autoimmune diseases (ADs). Mechanistic studies recently provided the proof-of …

B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and
influenced by different patient, donor, and treatment related factors. In this review we …

Over the past 20 years, immunoablation followed by transplantation of autologous
haematopoietic stem cells (ASCT) has emerged as a promising treatment option for patients …

The clinical experience gathered throughout the years has raised awareness of primary
immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa …

B-cell immune dysfunction contributes to the risk of severe infections after allogeneic
hematopoietic stem cell transplantation (allo-HSCT). Delayed B-cell regeneration is found in …

Numerous studies have shown evidence supporting the benefits of universal newborn
screening for primary immunodeficiencies (PID) and for Spinal Muscular Atrophy (SMA). We …

Early diagnosis of severe combined immunodeficiency (SCID), spinal muscular atrophy
(SMA), and sickle cell disease (SCD) improves health outcomes by providing a specific …