[HTML][HTML] The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

[HTML][HTML] Inflammation context in Alzheimer's disease, a relationship intricate to define

C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological Research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

[HTML][HTML] Emerging applications of nanotechnology in healthcare systems: Grand challenges and perspectives

S Anjum, S Ishaque, H Fatima, W Farooq, C Hano… - Pharmaceuticals, 2021 - mdpi.com
Healthcare, as a basic human right, has often become the focus of the development of
innovative technologies. Technological progress has significantly contributed to the …

[HTML][HTML] Cellular infiltration in traumatic brain injury

A Alam, EP Thelin, T Tajsic, DZ Khan, A Khellaf… - Journal of …, 2020 - Springer
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

RJ Henry, RM Ritzel, JP Barrett, SJ Doran… - Journal of …, 2020 - Soc Neuroscience
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

[HTML][HTML] NLRP3 inflammasome in neurological diseases, from functions to therapies

L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling

S Xu, J Wang, J Zhong, M Shao, J Jiang… - Clinical and …, 2021 - Wiley Online Library
Background Neuroinflammation‐induced secondary injury is an important cause of
sustained progression of spinal cord injury. Inflammatory programmed cell death pyroptosis …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

[HTML][HTML] Targeting microglial activation states as a therapeutic avenue in Parkinson's disease

SR Subramaniam, HJ Federoff - Frontiers in aging neuroscience, 2017 - frontiersin.org
Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …