A notable advancement of the mechanochemical process has been its ability to initiate
reactions that are otherwise extremely difficult/impossible to accomplish. For the first time, in …

In the last years, numerous protocols have been published using ball milling for organic
synthesis. Compared to other methods such as microwave or ultrasound irradiation and …

A series of isoniazid derivatives bearing a phenolic or heteroaromatic coupled frame were
obtained by mechanochemical means. Their pH stability and their structural …

Chiral vicinal diamines represent an important class of organic building blocks that play
essential roles in various fields in chemical and material sciences. Their syntheses have …

Phenazines are known to exhibit a diverse range of biological properties, such as
antimicrobial, antitumor, antioxidant, antimalarial, neuroprotectant, etc. Owing to their …

Azines, pyrazoles, and pyridazinones were isolated as the sole products in high yields (>
97%) by grinding solid hydrazine (H3N+ NHCO2−) with di-carbonyl compounds or by their …

A series of hydrazones, as potential therapeutic agents, were successfully synthesized in a
vibratory ball-mill from various substituted organic hydrazines and phenol aldehydes. The …

Abstract Development of newer synthetic methodologies to access medium ring–sized
heterocyclic compounds is an important current activity, partly because of the biological and …

This review aims to present the application of ball milling for the synthesis ofdifferent
heterocyclic compounds in very good yields. The method is a simple, economical, and …

Green Chemistry has become in the last two decades an increasing part of research interest.
Nonconventional «green» sources for chemical reactions include micro-wave, mechanical …