Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …

Treatment of chronic kidney disease (CKD) can slow its progression to end-stage renal
disease (ESRD). However, the therapies remain limited. Blood pressure control using …

Background Asymptomatic hyperuricemia increases renal and cardiovascular (CV) risk. We
previously conducted a 2-year, single-blind, randomized, controlled trial of allopurinol …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide. Some
studies have suggested anassociation between serum uric acid levels and cardiovascular …

Several epidemiological studies report a positive correlation between hyperuricemia and
metabolic syndrome (MetS) in adults, which hyperuricemic subjects seem to more easily …

Emerging data show that increased serum uric acid (SUA) concentration is an independent
risk factor for end-stage renal disease. Treatment with the antihypertensive drug losartan …

Background and objectives The effects of uric acid-lowering therapy in patients with chronic
kidney disease (CKD) remain uncertain. Therefore, we undertook a systematic review and …

Aims To investigate the relationship between hyperuricemia (HUA) and the clinical
backgrounds in Japanese patients with type 2 diabetes mellitus. Methods After a cross …

Chronic non-communicable diseases (NCD) that manifest primarily later in life, such as
cancer, cardiovascular disease, diabetes and chronic obstructive pulmonary disease …

BACKGROUND: Hyperuricemia may be involved in the atherosclerotic process due to
endothelial dysfunction and facilitation of smooth muscle cell proliferation. However …