Pathogenicity and virulence of Clostridioides difficile

JE Buddle, RP Fagan - Virulence, 2023 - Taylor & Francis
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

[HTML][HTML] Insights into gut dysbiosis: inflammatory diseases, obesity, and restoration approaches

A Acevedo-Román, N Pagán-Zayas… - International Journal of …, 2024 - mdpi.com
The gut microbiota is one of the most critical factors in human health. It involves numerous
physiological processes impacting host health, mainly via immune system modulation. A …

Mouse models for bacterial enteropathogen infections: insights into the role of colonization resistance

MKM Herzog, M Cazzaniga, A Peters, N Shayya… - Gut …, 2023 - Taylor & Francis
Globally, enteropathogenic bacteria are a major cause of morbidity and mortality. 1-3
Campylobacter, Salmonella, Shiga-toxin-producing Escherichia coli, and Listeria are among …

Gut metabolites predict Clostridioides difficile recurrence

JJ Dawkins, JR Allegretti, TE Gibson, E McClure… - Microbiome, 2022 - Springer
Background Clostridioides difficile infection (CDI) is the most common hospital acquired
infection in the USA, with recurrence rates> 15%. Although primary CDI has been …

Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection

AS McMillan, G Zhang, MK Dougherty, SK McGill… - Msphere, 2024 - journals.asm.org
Recurrent C. difficile infection (rCDI) is an urgent public health threat, for which the last resort
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

C Dureja, JT Rutherford, FBA Pavel… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired diarrhea, which
often stems from disruption of the gut microbiota by broad-spectrum antibiotics. The …

Risk Factors, Diagnosis, and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease

LE Del Vecchio, M Fiorani, E Tohumcu, S Bibbò… - Microorganisms, 2022 - mdpi.com
Clostridioides difficile infection (CDI) and inflammatory bowel disease (IBD) are two
pathologies that share a bidirectional causal nexus, as CDI is known to have an aggravating …

What's a Biofilm?—How the Choice of the Biofilm Model Impacts the Protein Inventory of Clostridioides difficile

M Brauer, C Lassek, C Hinze, J Hoyer… - Frontiers in …, 2021 - frontiersin.org
The anaerobic pathogen Clostridioides difficile is perfectly equipped to survive and persist
inside the mammalian intestine. When facing unfavorable conditions C. difficile is able to …

Systematic Review and Meta-Analysis on the Frequency of Antibiotic-Resistant Clostridium Species in Saudi Arabia

SS Banawas - Antibiotics, 2022 - mdpi.com
Clostridium is a genus comprising Gram-positive, rod-shaped, spore-forming, anaerobic
bacteria that cause a variety of diseases. However, there is a shortage of information …

Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics

AS McMillan, CM Theriot - Gut Microbes, 2024 - Taylor & Francis
Clostridioides difficile is a major nosocomial pathogen, causing significant morbidity and
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …