CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …

Demanded as an essential trace element that supports cell growth and basic functions, iron
can be harmful and cancerogenic though. By exchanging between its different oxidized …

Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …

Background: Ischemic heart disease remains a leading cause of death worldwide. In this
study, we test the hypothesis that microRNA-210 protects the heart from myocardial …

Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by
an incomplete understanding of how nanoparticle structure affects biodistribution to off …

Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …