Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they
control a variety of neuronal functions. Due to their roles in a number of CNS processes …

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …

Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are
emerging as important targets for the development of novel treatments for the symptoms …

Dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of
the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that …

Central nervous system cholinergic neurons arise from several discrete sources, project to
multiple brain regions, and exert specific effects on reward, learning, and memory. These …

Mu-opioid agonists (eg, oxycodone) are highly effective therapeutics for pain. However, they
also produce reinforcing effects that increase their likelihood of abuse. Recent strategies in …

The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …

The human M5 muscarinic acetylcholine receptor (mAChR) has recently emerged as an
exciting therapeutic target for treating a range of disorders, including drug addiction …

There is substantial evidence that cholinergic system function impairment plays a significant
role in many central nervous system (CNS) disorders. During the past three decades …