Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …
fundamental central and peripheral functions. The lack of small-molecule ligands that can …
Muscarinic acetylcholine receptors as CNS drug targets
CJ Langmead, J Watson, C Reavill - Pharmacology & therapeutics, 2008 - Elsevier
Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they
control a variety of neuronal functions. Due to their roles in a number of CNS processes …
control a variety of neuronal functions. Due to their roles in a number of CNS processes …
Targeting muscarinic acetylcholine receptors for the treatment of psychiatric and neurological disorders
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …
behaviors such as cognition, movement, and reward, making them ideally situated as …
[HTML][HTML] Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia
Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are
emerging as important targets for the development of novel treatments for the symptoms …
emerging as important targets for the development of novel treatments for the symptoms …
Acetylcholine–dopamine interactions in the pathophysiology and treatment of CNS disorders
Dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of
the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that …
the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that …
[HTML][HTML] The role of acetylcholine in cocaine addiction
MJ Williams, B Adinoff - Neuropsychopharmacology, 2008 - nature.com
Central nervous system cholinergic neurons arise from several discrete sources, project to
multiple brain regions, and exert specific effects on reward, learning, and memory. These …
multiple brain regions, and exert specific effects on reward, learning, and memory. These …
The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats
CA Zamarripa, SR Edwards, HN Qureshi… - Drug and Alcohol …, 2018 - Elsevier
Mu-opioid agonists (eg, oxycodone) are highly effective therapeutics for pain. However, they
also produce reinforcing effects that increase their likelihood of abuse. Recent strategies in …
also produce reinforcing effects that increase their likelihood of abuse. Recent strategies in …
Muscarinic receptor pharmacology and circuitry for the modulation of cognition
The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …
Crystal structure of the M5 muscarinic acetylcholine receptor
Z Vuckovic, PR Gentry, AE Berizzi… - Proceedings of the …, 2019 - National Acad Sciences
The human M5 muscarinic acetylcholine receptor (mAChR) has recently emerged as an
exciting therapeutic target for treating a range of disorders, including drug addiction …
exciting therapeutic target for treating a range of disorders, including drug addiction …
[HTML][HTML] Drug design targeting the muscarinic receptors and the implications in central nervous system disorders
There is substantial evidence that cholinergic system function impairment plays a significant
role in many central nervous system (CNS) disorders. During the past three decades …
role in many central nervous system (CNS) disorders. During the past three decades …