Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
SK Powers, MJ Jackson - Physiological reviews, 2008 - journals.physiology.org
The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …
[HTML][HTML] Reactive oxygen species: impact on skeletal muscle
It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …
species. Although the sources of oxidant production during exercise continue to be debated …
Exercise-induced oxidative stress in humans: cause and consequences
The observation that muscular exercise is associated with oxidative stress in humans was
first reported over 30years ago. Since this initial report, numerous studies have confirmed …
first reported over 30years ago. Since this initial report, numerous studies have confirmed …
Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload
S Wagner, HM Ruff, SL Weber, S Bellmann… - Circulation …, 2011 - Am Heart Assoc
Rationale: In heart failure Ca/calmodulin kinase (CaMK) II expression and reactive oxygen
species (ROS) are increased. Both ROS and CaMKII can increase late I Na leading to …
species (ROS) are increased. Both ROS and CaMKII can increase late I Na leading to …
[HTML][HTML] SR/ER–mitochondrial local communication: calcium and ROS
G Csordás, G Hajnóczky - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support
signal transduction and biosynthetic pathways and affect organellar distribution. Recently …
signal transduction and biosynthetic pathways and affect organellar distribution. Recently …
[HTML][HTML] Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice
J Shan, MJ Betzenhauser, A Kushnir… - The Journal of …, 2010 - Am Soc Clin Investig
Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine
receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) …
receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) …
Oxidative stress–induced afterdepolarizations and calmodulin kinase II signaling
LH Xie, F Chen, HS Karagueuzian… - Circulation research, 2009 - Am Heart Assoc
In the heart, oxidative stress caused by exogenous H2O2 has been shown to induce early
afterdepolarizations (EADs) and triggered activity by impairing Na current (I Na) inactivation …
afterdepolarizations (EADs) and triggered activity by impairing Na current (I Na) inactivation …
Activation of transient receptor potential ankyrin 1 by hydrogen peroxide
Y Sawada, H Hosokawa, K Matsumura… - European Journal of …, 2008 - Wiley Online Library
Abstract Hydrogen peroxide (H2O2), which is contained in industrial products, is also
generated within cells. H2O2 causes pain but it has not been elucidated how it activates …
generated within cells. H2O2 causes pain but it has not been elucidated how it activates …
[HTML][HTML] Ryanodine receptor 1-related myopathies: diagnostic and therapeutic approaches
TA Lawal, JJ Todd, KG Meilleur - Neurotherapeutics, 2018 - Elsevier
Ryanodine receptor type 1-related myopathies (RYR1-RM) are the most common class of
congenital myopathies. Historically, RYR1-RM classification and diagnosis have been …
congenital myopathies. Historically, RYR1-RM classification and diagnosis have been …
Redox regulation of sodium and calcium handling
S Wagner, AG Rokita, ME Anderson… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: In heart failure (HF), contractile dysfunction and arrhythmias result from
disturbed intracellular Ca handling. Activated stress kinases like cAMP-dependent protein …
disturbed intracellular Ca handling. Activated stress kinases like cAMP-dependent protein …