For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Abstract Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in
mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low …

Aims Superficial erosion of atheromata causes many acute coronary syndromes, but arises
from unknown mechanisms. This study tested the hypothesis that Toll-like receptor-2 (TLR2) …

Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in
COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme …

Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating
degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules …

The content of proteoglycans (PGs) is low in the extracellular matrix (ECM) of vascular
tissue, but increases dramatically in all phases of vascular disease. Early studies …

Innate immune receptors, well known mediators of response to non-self-molecules and
inflammation, also act as mediators of immunity triggered by 'damage-associated molecular …

Objectives: This study sought to determine whether splenic activation after acute coronary
syndrome (ACS) is linked to leukocyte proinflammatory remodeling and whether splenic …