Observation of conformational changes that underlie the catalytic cycle of Xrn2
JH Overbeck, D Stelzig, AL Fuchs, JP Wurm… - Nature chemical …, 2022 - nature.com
Nuclear magnetic resonance (NMR) methods that quantitatively probe motions on molecular
and atomic levels have propelled the understanding of biomolecular processes for which …
and atomic levels have propelled the understanding of biomolecular processes for which …
Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing
US Athapattu, CA Amarasekara, JR Immel… - Nucleic acids …, 2021 - academic.oup.com
Modifications in RNA are numerous (∼ 170) and in higher numbers compared to DNA (∼ 5)
making the ability to sequence an RNA molecule to identify these modifications highly …
making the ability to sequence an RNA molecule to identify these modifications highly …
FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila
N Kaul, SJ Pradhan, NG Boin, MM Mason, J Rosales… - RNA biology, 2024 - Taylor & Francis
ABSTRACT Fragile X Syndrome (FXS) is the most common inherited form of intellectual
disability and is caused by mutations in the gene encoding the Fragile X messenger …
disability and is caused by mutations in the gene encoding the Fragile X messenger …
RNA structure protects the 5′ end of an uncapped tombusvirus RNA genome from Xrn digestion
CD Gunawardene, JSH Im, KA White - Journal of Virology, 2021 - Am Soc Microbiol
One of the many challenges faced by RNA viruses is the maintenance of their genomes
during infections of host cells. Members of the family Tombusviridae are plus-strand RNA …
during infections of host cells. Members of the family Tombusviridae are plus-strand RNA …
Structure-Based Regulatory Role for the 5′ UTR of RCNMV RNA2
JSH Im, JR Sheppard, KA White - Viruses, 2023 - mdpi.com
Red clover necrotic mosaic virus (RCNMV) is a segmented positive-strand RNA virus
consisting of RNA1 and RNA2. Previous studies demonstrated that efficient translation of …
consisting of RNA1 and RNA2. Previous studies demonstrated that efficient translation of …
[HTML][HTML] Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation
S Mondal, J Zahumensky, P Vesela, J Malinsky - Heliyon, 2024 - cell.com
The regulation of gene expression in eukaryotes relies largely on the action of
exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger …
exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger …
Comparison of Xrn1 and Rat1 5′→ 3′ exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay
JE Pérez‐Ortín, A Jordán‐Pla, Y Zhang… - Yeast, 2024 - Wiley Online Library
The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5′→ 3′
exoribonuclease paralogs. In yeast, they are called Xrn1, which shuttles between the …
exoribonuclease paralogs. In yeast, they are called Xrn1, which shuttles between the …
Processing of RNA containing 8-Oxo-7, 8-dihydroguanosine (8-oxoG) by the exoribonuclease Xrn-1
CN Phillips, S Schowe, CJ Langeberg… - Frontiers in Molecular …, 2021 - frontiersin.org
Understanding how oxidatively damaged RNA is handled intracellularly is of relevance due
to the link between oxidized RNA and the progression/development of some diseases as …
to the link between oxidized RNA and the progression/development of some diseases as …
Global Characterization of XRN 5′-3′ Exoribonucleases and Their Responses to Environmental Stresses in Plants
The XRN family of 5′-3′ Exoribonucleases is functionally conserved in eukaryotic
organisms. However, the molecular evolution of XRN proteins in plants and their functions in …
organisms. However, the molecular evolution of XRN proteins in plants and their functions in …
MrXrn1 基因参与调控罗伯茨绿僵菌的产孢和致病
汪章勋， 徐秀珍， 冯健雨， 周权， 黄勃 - 中国生物防治学报, 2020 - zgswfz.com.cn
本研究以罗伯茨绿僵菌为研究对象, 针对5'-3'核糖核酸外切酶基因(MrXrn1, MAA_09154, 5'-
3'exoribonuclease 1), 利用农杆菌介导的同源重组方法进行基因敲除. 对获得的MrXrn1 …
3'exoribonuclease 1), 利用农杆菌介导的同源重组方法进行基因敲除. 对获得的MrXrn1 …