In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …

Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

Background This is the second update of previously published reviews in the Cochrane
Library (2015, first update 2017). Interleukin‐5 (IL‐5) is the main cytokine involved in the …

Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …

Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction
and are associated with chronic inflammation of the airways. However, the nature and sites …

Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …

Maintaining research and development (R&D) productivity at a sustainable level is one of
the main challenges currently facing the pharmaceutical industry. In this article, we discuss …