A materials science vision of extracellular matrix mineralization
From an engineering perspective, skeletal tissues are remarkable structures because they
are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical …
are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical …
Natural load-bearing protein materials
MJ Harrington, P Fratzl - Progress in Materials Science, 2021 - Elsevier
Biological tissues in animals generally consist an extracellular matrix often with cells
embedded in it. These materials are primarily comprised of different protein building blocks …
embedded in it. These materials are primarily comprised of different protein building blocks …
Mineralization generates megapascal contractile stresses in collagen fibrils
H Ping, W Wagermaier, N Horbelt, E Scoppola, C Li… - Science, 2022 - science.org
During bone formation, collagen fibrils mineralize with carbonated hydroxyapatite, leading to
a hybrid material with excellent properties. Other minerals are also known to nucleate within …
a hybrid material with excellent properties. Other minerals are also known to nucleate within …
Fractal-like hierarchical organization of bone begins at the nanoscale
INTRODUCTION The components of bone assemble hierarchically to provide stiffness and
toughness. Deciphering the specific organization and relationship between bone's principal …
toughness. Deciphering the specific organization and relationship between bone's principal …
The relevance of structural features of cellulose and its interactions to dissolution, regeneration, gelation and plasticization phenomena
Cellulose is the most abundant polymer and a very important renewable resource. Since
cellulose cannot be shaped by melting, a major route for its use for novel materials, new …
cellulose cannot be shaped by melting, a major route for its use for novel materials, new …
Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization
Contemporary models of intrafibrillar mineralization mechanisms are established using
collagen fibrils as templates without considering the contribution from collagen-bound …
collagen fibrils as templates without considering the contribution from collagen-bound …
Collagen fibrils mechanically contribute to tissue contraction in an in vitro wound healing scenario
E Brauer, E Lippens, O Klein, G Nebrich… - Advanced …, 2019 - Wiley Online Library
Wound contraction is an ancient survival mechanism of vertebrates that results from tensile
forces supporting wound closure. So far, tissue tension was attributed to cellular forces …
forces supporting wound closure. So far, tissue tension was attributed to cellular forces …
Scaffold curvature-mediated novel biomineralization process originates a continuous soft tissue-to-bone interface
M Paris, A Götz, I Hettrich, CM Bidan, JWC Dunlop… - Acta biomaterialia, 2017 - Elsevier
A myriad of shapes are found in biological tissues, often naturally evolved to fulfill a
particular function. In the field of tissue engineering, substrate geometry influences cell …
particular function. In the field of tissue engineering, substrate geometry influences cell …
Biological stenciling of mineralization in the skeleton: local enzymatic removal of inhibitors in the extracellular matrix
Biomineralization is remarkably diverse and provides myriad functions across many
organismal systems. Biomineralization processes typically produce hardened, hierarchically …
organismal systems. Biomineralization processes typically produce hardened, hierarchically …
Ultrastructure and nanoporosity of human bone shown with correlative on-axis electron and spectroscopic tomographies
Mineralized collagen fibrils are the building block units of bone at the nanoscale. While it is
known that collagen fibrils are mineralized both inside their gap zones (intra-fibrillar …
known that collagen fibrils are mineralized both inside their gap zones (intra-fibrillar …