Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

The four-membered oxetane ring has been increasingly exploited for its contrasting
behaviors: its influence on physicochemical properties as a stable motif in medicinal …

Taxol (a brand name for paclitaxel) is widely regarded as among the most famed natural
isolates ever discovered, and has been the subject of innumerable studies in both basic and …

Natural products containing eight-membered carbocycles constitute a class of structurally
intriguing and biologically important molecules such as the famous diterpenes taxol and …

Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …

Paclitaxel is the first microtubule-stabilizing agent identified and considered to be the most
significant advance in chemotherapy of the past two decades. It is considered one of the …

Taxol is one of the most famous natural diterpenoids and an important anticancer medicine.
Taxol represents a formidable synthetic challenge and has prompted significant interest from …

Chemical synthesis of natural products is typically inspired by the structure and function of a
target molecule. When both factors are of interest, such as in the case of taxane …

Taxol (1) is a clinically used antineoplastic diterpenoid. The tetracyclic ring system
comprises a 6/8/6-membered carbocycle (ABC-ring) and a fused oxetane ring (D-ring) …