A molecular understanding of high-density lipoprotein (HDL) will allow a more complete
grasp of its interactions with key plasma remodelling factors and with cell-surface proteins …

Apolipoprotein (apo) AI is the principal protein component of HDL, and because of its
conformational adaptability, it can stabilize all HDL subclasses. The amphipathic α-helix is …

Phospholipid bilayer Nanodiscs are novel model membranes derived from high-density
lipoprotein particles and have proven to be useful in studies of membrane proteins …

High-density lipoproteins (HDLs) mediate cholesterol transport and protection from
cardiovascular disease. Although synthetic HDLs have been studied for 30 years, the …

Accumulation of low-density lipoprotein (LDL)-derived cholesterol by artery wall
macrophages triggers atherosclerosis, the leading cause of cardiovascular disease …

Spherical high density lipoproteins (HDL)† predominate in human plasma. However, little
information exists on the structure of the most common HDL protein, apolipoprotein (apo) AI …

Not long ago, high density lipoproteins (HDL) 2 were second class citizens with regard to
therapeutic strategies for lowering the risk of atherosclerosis and coronary artery disease …

HDL protects against vascular disease by accepting free cholesterol from macrophage foam
cells in the artery wall. This pathway is critically dependent on lecithin: cholesterol …

The cardioprotective function of high-density lipoprotein (HDL) is largely attributed to its
ability to facilitate transport of cholesterol from peripheral tissues to the liver. However, HDL …

A number of lipid-based technologies have been applied to pharmaceuticals to modify their
drug release characteristics, and additionally, to improve the drug loading for poorly soluble …