International AIDS Society global scientific strategy: towards an HIV cure 2016

SG Deeks, SR Lewin, AL Ross, J Ananworanich… - Nature medicine, 2016 - nature.com
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …

Persistent HIV-1 replication during antiretroviral therapy

J Martinez-Picado, SG Deeks - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
Persistent HIV-1 replication during antiretroviral therapy : Current Opinion in HIV and AIDS
Persistent HIV-1 replication during antiretroviral therapy : Current Opinion in HIV and AIDS Log …

Adeno-associated virus delivery of anti-HIV monoclonal antibodies can drive long-term virologic suppression

JM Martinez-Navio, SP Fuchs, SN Pantry, WA Lauer… - Immunity, 2019 - cell.com
Long-term delivery of anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus
(AAV) vectors holds promise for the prevention and treatment of HIV infection. We describe a …

Advances toward curing HIV-1 infection in tissue reservoirs

LJ Henderson, LB Reoma, JA Kovacs, A Nath - Journal of virology, 2020 - Am Soc Microbiol
ABSTRACT A disease of more than 39.6 million people worldwide, HIV-1 infection has no
curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to …

Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression

M Gisslen, SM Keating, S Spudich, V Arechiga… - PLoS …, 2021 - journals.plos.org
Objective To characterize the evolution of central nervous system (CNS) inflammation in HIV-
1 infection applying a panel of cerebrospinal fluid (CSF) inflammatory biomarkers to …

Luciferase immunoprecipitation systems for measuring antibodies in autoimmune and infectious diseases

PD Burbelo, EE Lebovitz, AL Notkins - Translational Research, 2015 - Elsevier
Antibody profiles have the potential to revolutionize personalized medicine by providing
important information related to autoimmunity against self-proteins and exposure to …

Select host restriction factors are associated with HIV persistence during antiretroviral therapy

M Abdel-Mohsen, C Wang, MC Strain, SM Lada… - Aids, 2015 - journals.lww.com
Objective: The eradication of HIV necessitates elimination of the HIV latent reservoir.
Identifying host determinants governing latency and reservoir size in the setting of …

HIV antibody level as a marker of HIV persistence and low-level viral replication

SM Keating, CD Pilcher, V Jain… - The Journal of …, 2017 - academic.oup.com
Background. Human immunodeficiency virus (HIV) antibodies are generated and
maintained by ongoing systemic expression of HIV antigen. We investigated whether HIV …

Frontline science: plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy

SK Vadrevu, I Trbojevic-Akmacic… - Journal of leukocyte …, 2018 - academic.oup.com
Global antibody glycosylation is dynamic and plays critical roles in shaping different
immunological outcomes and direct antibody functionality during HIV infection. However, the …