Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

New formulations, therapeutic switching of the established drugs amphotericin B and
paromomycin, and the serendipitous discovery of miltefosine have markedly improved …

Sterols are constituents of the cellular membranes that are essential for their normal
structure and function. In mammalian cells, cholesterol is the main sterol found in the various …

To understand the structural basis for bisphosphonate therapy of bone diseases, we solved
the crystal structures of human farnesyl pyrophosphate synthase (FPPS) in its unliganded …

ABSTRACT Introduction: Chagas disease affects 8–10 million people worldwide, mainly in
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …

The solution and solid state complexation features for two classes of diphosphonic acids:
with gem-phosphonic–phosphonate groups or with a CNC spacer between them are …

Modification of GTPases with isoprenoid molecules derived from geranylgeranyl
pyrophosphate or farnesyl pyrophosphate is an essential requisite for cellular signaling …

Background: Strategies for development of anti-parasite chemotherapy involve identification
of active principles of plants, investigation of drugs already licensed for other pathologies, or …

Chagas disease must be treated in all its stages: acute, indeterminate, chronic, and initial
and middle determinant chronic, due to the fact that DNA of the parasite can be …