Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

Bioluminescence resonance energy transfer (BRET) is a straightforward biophysical
technique for studying protein-protein interactions. It requires:(1) that proteins of interest and …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric
entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

There is evidence for strong functional antagonistic interactions between adenosine A 2A
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …

G protein‐coupled chemokine receptors and their peptidergic ligands are interesting
therapeutic targets due to their involvement in various immune‐related diseases, including …

The idea that G-protein-coupled receptors (GPCRs) can function as dimers is now generally
accepted. Although an increasing amount of data suggests that dimers represent the basic …

One‐third of the∼ 400 nonodorant G protein‐coupled receptors (GPCRs) are still orphans.
Although a considerable number of these receptors are likely to transduce cellular signals in …