The term PEGylation describes the modification of biological molecules by covalent
conjugation with polyethylene glycol (PEG), a non-toxic, non-immunogenic polymer, and is …

The paper discusses general problems in using PEG for conjugation to high or low
molecular weight molecules. Methods of binding PEG to different functional groups in …

Amino acid composition analysis is a classical protein analysis method, which finds a wide
application in medical and food science research and is indispensable for protein …

Polyethylene glycol (PEG) is widely used as a covalent modifier of biological
macromolecules and particulates as well as a carrier for low molecular weight drugs. In the …

One of the best biocompatible polymers, poly (ethylene glycol)(PEG),* 1 possesses an array
of useful properties (1, 2). Among them are a wide range of solubilities in both organic …

Procedures are described for linking monomethoxypoly (ethylene glycol)(mPEG) to both e
and a amino groups of lysine. The lysine carboxyl group can then be activated as a …

Synthesis of the vinyl sulfone and chloroethyl sulfone derivatives of poly (ethylene
glycol)(PEG) is described. The chloroethyl sulfone (CES-PEG) is rapidly converted to the …

The intricate problems associated with the delivery and various unnecessary in vivo
transitions of proteins and drugs needs to be tackled soon to be able to exploit the myriad of …

Polymer conjugation is of increasing interest in pharmaceutical chemistry for delivering
drugs of simple structure or complex compounds such peptides, enzymes and …

Linear and branched poly (ethylene glycol) s, with similar molecular weights, were
conjugated with uricase and asparaginase, and an investigation of enzymological …