[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders
It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …
that a neurocentric perspective of the integrative signal communication in the central …
[HTML][HTML] Class A and C GPCR dimers in neurodegenerative diseases
AB Caniceiro, B Bueschbell, AC Schiedel… - Current …, 2022 - ncbi.nlm.nih.gov
Neurodegenerative diseases affect over 30 million people worldwide with an ascending
trend. Most individuals suffering from these irreversible brain damages belong to the elderly …
trend. Most individuals suffering from these irreversible brain damages belong to the elderly …
Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex …
DO Borroto-Escuela, A Lopez-Salas… - Frontiers in Molecular …, 2023 - frontiersin.org
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-
6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of …
6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of …
Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers
The functional interactions between opioid and chemokine receptors have been implicated
in the pathological process of chronic pain. Mounting studies have indicated the possibility …
in the pathological process of chronic pain. Mounting studies have indicated the possibility …
[HTML][HTML] Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy
G protein-coupled receptors (GPCRs) play a pivotal role in fundamental biological
processes and disease development. GPCR isoforms, derived from alternative splicing, can …
processes and disease development. GPCR isoforms, derived from alternative splicing, can …
[HTML][HTML] AI's Role in Pharmaceuticals: Assisting Drug Design from Protein Interactions to Drug Development
S Bechelli, J Delhommelle - Artificial Intelligence Chemistry, 2023 - Elsevier
Developing new pharmaceutical compounds is a lengthy, costly, and intensive process. In
recent years, the development of Artificial Intelligence (AI), Machine Learning (ML), and …
recent years, the development of Artificial Intelligence (AI), Machine Learning (ML), and …
[PDF][PDF] CHARACTERIZATION OF PROTEIN-PROTEIN INTERACTIONS INVOLVING G PROTEIN-COUPLED RECEPTOR 143 BY COMPUTATIONAL AND …
I de Sousa Moreira - 2023 - estudogeral.uc.pt
Os recetores acoplados à proteína G (GPCRs) desempenham funções críticas no
desenvolvimento e progressão de diversas patologias. Muitos membros da família GPCR …
desenvolvimento e progressão de diversas patologias. Muitos membros da família GPCR …
Dasiel O. Borroto-Escuela,*, Alexander Lopez-Salas, Karolina Wydra, Marco Bartolini, Zilong Zhou, Malgorzata Frankowska, Agata Suder, Javier Benitez-Porres
W Romero-Fernandez, M Filip… - New Insights Into the …, 2023 - books.google.com
GPCR homoreceptor and heteroreceptor complexes in the central nervous system (CNS)
are integrated through allosteric receptor-receptor interactions. These interactions modulate …
are integrated through allosteric receptor-receptor interactions. These interactions modulate …