The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

The spreading epidemic of allergies and asthma has heightened interest in IgE, the central
player in the allergic response. The activity of IgE is associated with a network of proteins; …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

abstract IgE and mast cells play a pivotal role in various allergic diseases, including asthma,
allergic rhinitis, and urticaria. Treatment with omalizumab, a monoclonal anti-IgE antibody …

IgE, the key molecule in atopy has been shown to bind two receptors, FcεRI, the high‐affinity
receptor, and FcεRII (CD23), binding IgE with lower affinity. Whereas cross‐linking of IgE on …

CD23 is the low-affinity receptor for immunoglobulin (Ig) E and plays important roles in the
regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of …

The metalloproteinases TACE [tumour necrosis factor α-converting enzyme; also known as
ADAM17 (a disintegrin and metalloproteinase 17)] and ADAM10 are the primary enzymes …

The formation and maintenance of complex organs requires segregation of distinct cell
populations into defined territories (that is, cell sorting) and the establishment of boundaries …

The “a disintegrin and metalloproteases”(ADAMs) are membrane-anchored metzincins of
the adamalysin subfamily. This review gives an overview over the biological function and …

Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of
which are mediated through its two Fc receptors, Fcε RI and CD 23 (Fcε RII). IgE and its …