The ADAM metalloproteinases
DR Edwards, MM Handsley, CJ Pennington - Molecular aspects of …, 2008 - Elsevier
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …
and secreted proteins with important roles in regulating cell phenotype via their effects on …
IgE in allergy and asthma today
HJ Gould, BJ Sutton - Nature Reviews Immunology, 2008 - nature.com
The spreading epidemic of allergies and asthma has heightened interest in IgE, the central
player in the allergic response. The activity of IgE is associated with a network of proteins; …
player in the allergic response. The activity of IgE is associated with a network of proteins; …
Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes
D Sbardella, GF Fasciglione, M Gioia, C Ciaccio… - Molecular aspects of …, 2012 - Elsevier
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
Roles of omalizumab in various allergic diseases
Y Okayama, H Matsumoto, H Odajima… - Allergology …, 2020 - jstage.jst.go.jp
abstract IgE and mast cells play a pivotal role in various allergic diseases, including asthma,
allergic rhinitis, and urticaria. Treatment with omalizumab, a monoclonal anti-IgE antibody …
allergic rhinitis, and urticaria. Treatment with omalizumab, a monoclonal anti-IgE antibody …
The role of CD23 in the regulation of allergic responses
P Engeroff, M Vogel - Allergy, 2021 - Wiley Online Library
IgE, the key molecule in atopy has been shown to bind two receptors, FcεRI, the high‐affinity
receptor, and FcεRII (CD23), binding IgE with lower affinity. Whereas cross‐linking of IgE on …
receptor, and FcεRII (CD23), binding IgE with lower affinity. Whereas cross‐linking of IgE on …
CD23/FcεRII: molecular multi-tasking
CD23 is the low-affinity receptor for immunoglobulin (Ig) E and plays important roles in the
regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of …
regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of …
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
CI Caescu, GR Jeschke, BE Turk - Biochemical Journal, 2009 - portlandpress.com
The metalloproteinases TACE [tumour necrosis factor α-converting enzyme; also known as
ADAM17 (a disintegrin and metalloproteinase 17)] and ADAM10 are the primary enzymes …
ADAM17 (a disintegrin and metalloproteinase 17)] and ADAM10 are the primary enzymes …
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
The formation and maintenance of complex organs requires segregation of distinct cell
populations into defined territories (that is, cell sorting) and the establishment of boundaries …
populations into defined territories (that is, cell sorting) and the establishment of boundaries …
Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure
T Klein, R Bischoff - Journal of proteome research, 2011 - ACS Publications
The “a disintegrin and metalloproteases”(ADAMs) are membrane-anchored metzincins of
the adamalysin subfamily. This review gives an overview over the biological function and …
the adamalysin subfamily. This review gives an overview over the biological function and …
Structure and dynamics of IgE–receptor interactions: Fcε RI and CD 23/Fcε RII
BJ Sutton, AM Davies - Immunological reviews, 2015 - Wiley Online Library
Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of
which are mediated through its two Fc receptors, Fcε RI and CD 23 (Fcε RII). IgE and its …
which are mediated through its two Fc receptors, Fcε RI and CD 23 (Fcε RII). IgE and its …