Beneficial effects of natural flavonoids on neuroinflammation

Y Chen, F Peng, Z Xing, J Chen, C Peng… - Frontiers in …, 2022 - frontiersin.org
Neuroinflammation is the fundamental immune response against multiple factors in the
central nervous system and is characterized by the production of inflammatory mediators …

[HTML][HTML] Polyphenols as novel interventions for depression: exploring the efficacy, mechanisms of action, and implications for future research

E Gamage, R Orr, N Travica, MM Lane… - Neuroscience & …, 2023 - Elsevier
Numerous animal and human studies have assessed the relationship between polyphenols
and outcomes related to depression. However, no comprehensive synthesis of the main …

Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …

B Ben-Azu, OG Adebayo, EG Moke… - Journal of Psychiatric …, 2023 - Elsevier
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …

Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae

B Ben-Azu, EG Moke, LE Chris-Ozoko… - …, 2024 - Springer
Rationale Emerging evidence indicates that persistent alcohol consumption escalates
psychosocial trauma achieved by social defeat stress (SDS)-induced neurobiological …

Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …

JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

Preventive putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin

PI Ugwu, B Ben-Azu, SU Ugwu, CI Uruaka… - Brain Research …, 2022 - Elsevier
Derangements of neuroimmune, neurotrophic and neurochemical homeostasis have
important implications in psychosocial stress-induced psychopathologies. Whether …

Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced autophagy, hormonal dysregulation, testicular and brain oxidative stress, and …

CC Onyekweli, B Ben-Azu, OM Oyovwi… - Food and Chemical …, 2024 - Elsevier
This study investigated whether epigallocatechin-gallate (EGCG) could counteract the
detrimental effects of high-fat diet (HFD)-induced obesity in rats exposed to rapamycin …

Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of …

NA Omeiza, A Bakre, B Ben-Azu, AA Sowunmi… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Persistent ketamine insults to the central nervous system
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …

Naringin confers protection against psychosocial defeat stress-induced neurobehavioral deficits in mice: involvement of glutamic acid decarboxylase isoform-67, oxido …

OM Oladapo, B Ben-Azu, AM Ajayi, O Emokpae… - Journal of molecular …, 2021 - Springer
Psychosocial stress has been widely reported to contribute to psychiatric disturbances.
Perturbations in the enzymes of GABAergic and cholinergic systems have been implicated …

Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia

B Ben-Azu, EC Del Re, J VanderZwaag… - Frontiers in Cellular …, 2023 - frontiersin.org
Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …