Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

1. Background: the concept of 'endothelial dysfunc- deficiency of either the substrate for the
enzyme NO tion' synthase or one of its critical co-factors. Alterations of endothelial cell …

The major factors determining myocardial perfusion and oxygen delivery have been
elucidated over the past several decades, and this knowledge has been incorporated into …

Abstract Small arterioles (40–150 μm) contribute to the majority of vascular resistance within
organs and tissues. Under resting conditions, the basal tone of these vessels is determined …

Flow-induced dilation (FID) is dependent largely on hyperpolarization of vascular smooth
muscle cells (VSMCs) in human coronary arterioles (HCA) from patients with coronary …

The endothelium mediates a number of responses (relaxation or contraction) of arteries and
veins from animals and humans. The endothelium-dependent relaxations are due to the …

BACKGROUND It has been suggested that endothelium-related vasomotion is important in
the control of coronary circulation. Our goal was to determine if endothelium-dependent …

Background The ability of the coronary vascular bed to dilate and thus increase blood flow to
the myocardium may be impaired in coronary artery disease, even in regions of myocardium …

In hypercholesterolemic rabbits, oral L-arginine (the substrate for endothelium derived nitric
oxide) attenuates endothelial dysfunction and atheroma formation, but the effect in …

The endothelium is involved in the control of vascular tone and homeostasis. Risk factors for
arteriosclerosis, as well as other conditions have been shown to be associated with a …