Histone modifications and non-coding RNAs: mutual epigenetic regulation and role in pathogenesis

IV Bure, MV Nemtsova, EB Kuznetsova - International Journal of …, 2022 - mdpi.com
In the last few years, more and more scientists have suggested and confirmed that
epigenetic regulators are tightly connected and form a comprehensive network of regulatory …

Mesenchymal stem cell‐derived exosomes for effective cartilage tissue repair and treatment of osteoarthritis

YG Kim, J Choi, K Kim - Biotechnology journal, 2020 - Wiley Online Library
Osteoarthritis (OA) is one of the most common musculoskeletal diseases, caused by cellular
inflammatory responses and subsequent structural disruption in osteochondral extracellular …

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting …

G Mao, Z Zhang, S Hu, Z Zhang, Z Chang… - Stem cell research & …, 2018 - Springer
Background WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study
investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in …

[HTML][HTML] Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration

S Jiang, G Tian, Z Yang, X Gao, F Wang, J Li, Z Tian… - Bioactive materials, 2021 - Elsevier
Articular cartilage defect repair is a problem that has long plagued clinicians. Although
mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they …

Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration

CH Woo, HK Kim, GY Jung, YJ Jung… - Journal of …, 2020 - Taylor & Francis
Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most
common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most …

Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of …

X Liu, L Wang, C Ma, G Wang, Y Zhang… - Journal of orthopaedic …, 2019 - Springer
Background Platelet-rich plasma (PRP) provides a nonsurgical approach for treating
osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been …

Crosstalk among circRNA/lncRNA, miRNA, and mRNA in osteoarthritis

H Kong, ML Sun, XA Zhang, XQ Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA) is a joint disease that is pervasive in life, and the incidence and mortality
of OA are increasing, causing many adverse effects on people's life. Therefore, it is very vital …

Exosomes derived from miR-155-5p–overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating …

Z Wang, K Yan, G Ge, D Zhang, J Bai, X Guo… - Cell biology and …, 2021 - Springer
Synovial mesenchymal stem cells (SMSCs) have the potential to attenuate osteoarthritis
(OA)-induced injury. The role and mechanism of SMSC-derived exosomes (SMSC-Exos) …

Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis

G Mao, Y Xu, D Long, H Sun, H Li, R Xin… - Stem Cell Research & …, 2021 - Springer
Objectives Aberrations in exosomal circular RNA (circRNA) expression have been identified
in various human diseases. In this study, we investigated whether exosomal circRNAs could …

Mesenchymal stem cells under epigenetic control–the role of epigenetic machinery in fate decision and functional properties

A Walewska, A Janucik, M Tynecka, M Moniuszko… - Cell Death & …, 2023 - nature.com
Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that
can differentiate into cells of at least three mesodermal lineages, namely adipocytes …