Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

Macrophages represent a key cellular component of the liver, and are essential for
maintaining tissue homeostasis and ensuring rapid responses to hepatic injury. Our …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Our view on liver macrophages in the context of health and disease has been reformed by
the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages …

Phagocytes, including neutrophils and macrophages, have been suggested to function in a
cooperative way in the initial phase of inflammatory responses, but their interaction and …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Hepatic fibrosis is a common pathological process involving persistent liver injury with
various etiologies and subsequent inflammatory responses that occur in chronic liver …