Hybrid physics-based and data-driven modeling of vascular bifurcation pressure differences

NL Rubio, L Pegolotti, MR Pfaller, EF Darve… - Computers in Biology …, 2025 - Elsevier
Reduced-order models allow for the simulation of blood flow in patient-specific vasculatures.
They offer a significant reduction in computational cost and wait time compared to traditional …

Estimation of pulmonary vascular resistance for Glenn physiology

S Laudenschlager, S Schofield, N Drysdale, M Stone… - Plos one, 2024 - journals.plos.org
Children with single ventricle heart disease typically require a series of three operations,(1)
Norwood,(2) Glenn, and (3) Fontan, which ultimately results in complete separation of the …

Bayesian Windkessel calibration using optimized 0D surrogate models

J Richter, J Nitzler, L Pegolotti, K Menon… - arXiv preprint arXiv …, 2024 - arxiv.org
Boundary condition (BC) calibration to assimilate clinical measurements is an essential step
in any subject-specific simulation of cardiovascular fluid dynamics. Bayesian calibration …

Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations

PJ Nair, E Perra, DB McElhinney, AL Marsden… - medRxiv, 2024 - medrxiv.org
Blood pressure gradient (ΔP) across an aortic coarctation (CoA) is an important
measurement to diagnose CoA severity and guide treatment. While invasive cardiac …