Spatial light interference microscopy: principle and applications to biomedicine

X Chen, ME Kandel, G Popescu - Advances in optics and photonics, 2021 - opg.optica.org
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-
shifting interferometer, built onto a phase-contrast microscope, with white-light illumination …

Quantitative phase imaging for label-free analysis of cancer cells—focus on digital holographic microscopy

Z El-Schich, A Leida Mölder, A Gjörloff Wingren - Applied Sciences, 2018 - mdpi.com
To understand complex biological processes, scientists must gain insight into the function of
individual living cells. In contrast to the imaging of fixed cells, where a single snapshot of the …

[HTML][HTML] Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients

G Xi, W Guo, D Kang, J Ma, F Fu, L Qiu, L Zheng… - Theranostics, 2021 - ncbi.nlm.nih.gov
The notion of personalized medicine demands proper prognostic biomarkers to guide the
optimal therapy for an invasive breast cancer patient. However, various risk prediction …

Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer

K Fujita, H Kume, K Matsuzaki, A Kawashima, T Ujike… - Scientific reports, 2017 - nature.com
Extracellular vesicles (EVs) are microvesicles secreted from various cell types. We aimed to
discover a new biomarker for high Gleason score (GS) prostate cancer (PCa) in urinary EVs …

[HTML][HTML] Label-free colorectal cancer screening using deep learning and spatial light interference microscopy (SLIM)

JK Zhang, YR He, N Sobh, G Popescu - APL photonics, 2020 - pubs.aip.org
Current pathology workflow involves staining of thin tissue slices, which otherwise would be
transparent, followed by manual investigation under the microscope by a trained pathologist …

Quantitative phase imaging reveals matrix stiffness-dependent growth and migration of cancer cells

Y Li, MJ Fanous, KA Kilian, G Popescu - Scientific reports, 2019 - nature.com
Cancer progression involves complex signals within the tumor microenvironment that
orchestrate proliferation and invasive processes. The mechanical properties of the …

Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer

S Cameron, G Deblois, JR Hawley, A Qamra, S Zhou… - Oncogene, 2023 - nature.com
Predicting and treating recurrence in intermediate-risk prostate cancer patients remains a
challenge despite having identified genomic instability and hypoxia [,] as risk factors. This …

Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM)

H Majeed, TH Nguyen, ME Kandel, A Kajdacsy-Balla… - Scientific reports, 2018 - nature.com
Breast cancer is the most common type of cancer among women worldwide. The standard
histopathology of breast tissue, the primary means of disease diagnosis, involves manual …

Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging

H Majeed, C Okoro, A Kajdacsy-Balla… - … of biomedical optics, 2017 - spiedigitallibrary.org
Tumor progression in breast cancer is significantly influenced by its interaction with the
surrounding stromal tissue. Specifically, the composition, orientation, and alignment of …

Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer

R Bhardwaj, P Mishra - Molecular Pharmaceutics, 2023 - ACS Publications
Erythropoietin-producing hepatocellular (Eph) receptors and their ligands, ephrins, are the
largest subfamily of receptor tyrosine kinases (RTKs) that have emerged as a new class of …