The gut-brain axis is crucial to microbial-host interactions. The neurotransmitter serotonin is
primarily synthesized in the gastrointestinal (GI) tract, where it is secreted into the lumen and …

Drug repositioning is a revolution breakthrough of drug discovery that presents outstanding
privilege with already safer agents by scanning the existing candidates as therapeutic …

Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight
gain and metabolic alterations when administered orally to patients. Recently, we …

Monoamine oxidase (MAO) is a key enzyme responsible for the degradation of
neurotransmitters and trace amines. MAO has two subtypes (MAO-A and MAO-B) that are …

Gut-microbiota membership is associated with diverse neuropsychological outcomes,
including substance use disorders (SUDs). Here, we use mice colonized with Citrobacter …

Olanzapine (OLA) is a highly obesogenic second-generation antipsychotic (SGA). Recently
we demonstrated that, contrarily to OLA oral treatment, intraperitoneal (ip) administration …

Background Major depressive disorder (MDD) represents a challenge with high prevalence
and limited effectiveness of existing treatments, particularly in cases of treatment-resistant …

The classical small molecule neurotransmitters are essential for cell–cell signaling in the
nervous system for regulation of behaviors and physiological functions. Metabolomics …

Increased 5-hydroxytryptamine may be associated with the development and progression of
inflammatory bowel disease. In this study, we examined the suppressive effect of flavonoids …

Dynamic fluctuations in the distribution of catecholamines across the brain modulate the
responsiveness of vertebrates to social stimuli. Previous work demonstrates that green …