Global consequences of liver ischemia/reperfusion injury

C Nastos, K Kalimeris, N Papoutsidakis… - Oxidative medicine …, 2014 - Wiley Online Library
Liver ischemia/reperfusion injury has been extensively studied during the last decades and
has been implicated in the pathophysiology of many clinical entities following hepatic …

[HTML][HTML] Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi-tasking enzyme

MG Battelli, A Bolognesi, L Polito - … Acta (BBA)-Molecular Basis of Disease, 2014 - Elsevier
The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids

DEC Van Hoorn, RJ Nijveldt, PAM Van Leeuwen… - European journal of …, 2002 - Elsevier
The flavonoid family shows a high potential for inhibition of xanthine oxidase. Currently,
more than 4000 flavonoids are known. The data of this study indicate that a planar structure …

Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase

K Shibata, N Cregg, D Engelberts… - American journal of …, 1998 - atsjournals.org
Relative hypoventilation, involving passively—or “permissively”—generated hypercapnic
acidosis (HCA), may improve outcome by reducing ventilator-induced lung injury. However …

Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia: role in acute lung injury

PM Hassoun, FS Yu, CG Cote, JJ Zulueta… - American journal of …, 1998 - atsjournals.org
LPS and selected cytokines upregulate xanthine dehydrogenase/xanthine oxidase
(XDH/XO) in cellular systems. However, the effect of these factors on in vivo XDH/XO …

Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction

Y Zou, KJ Jung, JW Kim, BP Yu… - The FASEB journal, 2004 - Wiley Online Library
To investigate the status of soluble adhesion molecules (sAMs) during aging, the present
study determined protein levels of several major sAMs in serum samples obtained from rats …

The effect of antioxidant supplementation on bacterial translocation after intestinal ischemia and reperfusion

A Tassopoulos, A Chalkias, A Papalois… - Redox …, 2017 - Taylor & Francis
The intestine is highly sensitive to ischemia/reperfusion (I/R) injury. Intestinal I/R may cause
local tissue injury and disruption of the intestinal mucosal barrier, allowing the passage of …

Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera

F Nessa, Z Ismail, N Mohamed - Pharmaceutical biology, 2010 - Taylor & Francis
Context: Blumea balsamifera DC (Compositae) leaves have been recommended for use as
a folk medicine in the treatment of various diseases related to urolithiasis in southeast Asia …

Febuxostat protects rats against lipopolysaccharide-induced lung inflammation in a dose-dependent manner

ANA Fahmi, GSG Shehatou, AM Shebl… - … archives of pharmacology, 2016 - Springer
The aim of the present work was to investigate possible protective effects of febuxostat, a
highly potent xanthine oxidase inhibitor, against acute lung injury (ALI) induced by …

Lung oxidative stress as related to exercise and altitude. Lipid peroxidation evidence in exhaled breath condensate: a possible predictor of acute mountain sickness

OF Araneda, C García, N Lagos, G Quiroga… - European Journal of …, 2005 - Springer
Lung oxidative stress (OS) was explored in resting and in exercising subjects exposed to
moderate and high altitude. Exhaled breath condensate (EBC) was collected under field …