[HTML][HTML] Lessons from HeLa cells: the ethics and policy of biospecimens

LM Beskow - Annual review of genomics and human genetics, 2016 - annualreviews.org
Human biospecimens have played a crucial role in scientific and medical advances.
Although the ethical and policy issues associated with biospecimen research have long …

Preanalytical variables affecting the integrity of human biospecimens in biobanking

C Ellervik, J Vaught - Clinical chemistry, 2015 - academic.oup.com
BACKGROUND Most errors in a clinical chemistry laboratory are due to preanalytical errors.
Preanalytical variability of biospecimens can have significant effects on downstream …

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

[HTML][HTML] Aspects of modern biobank activity–comprehensive review

W Paskal, AM Paskal, T Dębski, M Gryziak… - Pathology & Oncology …, 2018 - Springer
Biobanks play an increasing role in contemporary research projects. These units meet all
requirements to regard them as a one of the most innovative and up-to-date in the field of …

[HTML][HTML] Extracting research-quality phenotypes from electronic health records to support precision medicine

WQ Wei, JC Denny - Genome medicine, 2015 - Springer
The convergence of two rapidly developing technologies-high-throughput genotyping and
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …

Factors that drive the increasing use of FFPE tissue in basic and translational cancer research

EF Gaffney, PH Riegman, WE Grizzle… - Biotechnic & …, 2018 - Taylor & Francis
The decision to use 10% neutral buffered formalin fixed, paraffin embedded (FFPE) archival
pathology material may be dictated by the cancer research question or analytical technique …

[HTML][HTML] Genes, cells, and biobanks: Yes, there's still a consent problem

T Caulfield, B Murdoch - PLoS biology, 2017 - journals.plos.org
From a research perspective, the interest in biobanking continues to intensify. Governments
and industry have invested heavily in biobanks, as exemplified by initiatives like the United …

[HTML][HTML] Stakeholder engagement in policy development: challenges and opportunities for human genomics

AA Lemke, JN Harris-Wai - Genetics in Medicine, 2015 - Elsevier
Along with rapid advances in human genomics, policies governing genomic data and
clinical technologies have proliferated. Stakeholder engagement is widely lauded as an …

[HTML][HTML] The evolution of a large biobank at Mass General Brigham

NT Boutin, SB Schecter, EF Perez… - Journal of Personalized …, 2022 - mdpi.com
The Mass General Brigham Biobank (formerly Partners HealthCare Biobank) is a large
repository of biospecimens and data linked to extensive electronic health record data and …

Biobanks and electronic medical records: enabling cost-effective research

E Bowton, JR Field, S Wang, JS Schildcrout… - Science translational …, 2014 - science.org
The use of electronic medical record data linked to biological specimens in health care
settings is expected to enable cost-effective and rapid genomic analyses. Here, we present …