Patient-derived xenograft models in cancer therapy: technologies and applications
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
[HTML][HTML] Imaging drug delivery to the lungs: Methods and applications in oncology
Direct delivery to the lung via inhalation is arguably one of the most logical approaches to
treat lung cancer using drugs. However, despite significant efforts and investment in this …
treat lung cancer using drugs. However, despite significant efforts and investment in this …
Systematic comparison of pancreatic ductal adenocarcinoma models identifies a conserved highly plastic basal cell state
Intratumoral heterogeneity and cellular plasticity have emerged as hallmarks of cancer,
including pancreatic ductal adenocarcinoma (PDAC). As PDAC portends a dire prognosis, a …
including pancreatic ductal adenocarcinoma (PDAC). As PDAC portends a dire prognosis, a …
A pancreas tumor derived organoid study: from drug screen to precision medicine
J Yao, M Yang, L Atteh, P Liu, Y Mao, W Meng… - Cancer cell …, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite
considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality …
considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality …
[HTML][HTML] In vivo Mouse Models of Pancreatic Ductal Adenocarcinoma
CM Reyes, P Gärtner, L Rosenkranz… - Pancreapedia: The …, 2021 - pancreapedia.org
Since the introduction of the first genetically engineered mouse models (GEMM) based on
oncogene expression of Myc and TGFαvia the elastase promoter, GEMMs have provided an …
oncogene expression of Myc and TGFαvia the elastase promoter, GEMMs have provided an …
Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through …
J Russell, L Fanchon, H Alwaseem… - Pharmacology …, 2022 - Wiley Online Library
Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐
uniform distribution of activity throughout a murine pancreatic model. This is in contrast both …
uniform distribution of activity throughout a murine pancreatic model. This is in contrast both …