[HTML][HTML] Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives

A Vaiserman, D Krasnienkov - Frontiers in genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Association between the Oxidative Balance Score and Telomere Length from the National Health and Nutrition Examination Survey 1999‐2002

W Zhang, SF Peng, L Chen, HM Chen… - Oxidative medicine …, 2022 - Wiley Online Library
Purpose. Leukocyte telomere length (LTL) is an important biomarker of aging. The oxidative
balance score (OBS) is used to assess the oxidative stress‐related exposures of diet and …

[HTML][HTML] Cigarette smoking and telomere length: a systematic review of 84 studies and meta-analysis

Y Astuti, A Wardhana, J Watkins, W Wulaningsih - Environmental research, 2017 - Elsevier
Background Cigarette smoking is a risk factor for ageing-related disease, but its association
with biological ageing, indicated by telomere length, is unclear. Methods We systematically …

[HTML][HTML] Obesity may accelerate the aging process

V Salvestrini, C Sell, A Lorenzini - Frontiers in endocrinology, 2019 - frontiersin.org
Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

[HTML][HTML] T cell immunosenescence in aging, obesity, and cardiovascular disease

K Shirakawa, M Sano - Cells, 2021 - mdpi.com
Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

[HTML][HTML] Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies

M Gielen, GJ Hageman, EE Antoniou, K Nordfjall… - The American journal of …, 2018 - Elsevier
Background Even before the onset of age-related diseases, obesity might be a contributing
factor to the cumulative burden of oxidative stress and chronic inflammation throughout the …

Physical activity and telomere length in US men and women: An NHANES investigation

LA Tucker - Preventive medicine, 2017 - Elsevier
The principal objective was to determine the extent to which physical activity (PA) accounts
for differences in leukocyte telomere length (LTL) in a large random sample of US adults …

[HTML][HTML] Inflammation as a precursor of atherothrombosis, diabetes and early vascular aging

E Barbu, MR Popescu, AC Popescu… - International Journal of …, 2022 - mdpi.com
Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

Nutrients, foods, dietary patterns and telomere length: Update of epidemiological studies and randomized trials

TM Freitas-Simoes, E Ros, A Sala-Vila - Metabolism, 2016 - Elsevier
Identifying simple strategies to prevent or delay age-associated pathologies is a major
public health concern. Attrition of telomeres, chromatin structures that help maintain genome …