Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

[HTML][HTML] The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on …

C Vlachopoulos, P Xaplanteris, V Aboyans… - Atherosclerosis, 2015 - Elsevier
While risk scores are invaluable tools for adapted preventive strategies, a significant gap
exists between predicted and actual event rates. Additional tools to further stratify the risk of …

The assessment of endothelial function: from research into clinical practice

AJ Flammer, T Anderson, DS Celermajer, MA Creager… - Circulation, 2012 - Am Heart Assoc
The discovery of nitric oxide (NO) as a crucial endothe-lium-derived molecule for vascular
relaxation and the recognition of the endothelium as more than a passive interface between …

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials …

D Keene, C Price, MJ Shun-Shin, DP Francis - Bmj, 2014 - bmj.com
Objective To investigate the effects on cardiovascular outcomes of drug interventions that
increase high density lipoprotein levels. Design Meta-analysis. Studies reviewed …

Calcific aortic stenosis: a disease of the valve and the myocardium

MR Dweck, NA Boon, DE Newby - Journal of the American College of …, 2012 - jacc.org
Although aortic stenosis is a common condition associated with major morbidity, mortality,
and health economic costs, there are currently no medical interventions capable of delaying …

Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport

RS Rosenson, HB Brewer Jr, WS Davidson, ZA Fayad… - Circulation, 2012 - Am Heart Assoc
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic
properties, including the ability to mediate macrophage cholesterol efflux, antioxidant …

Imaging atherosclerosis

JM Tarkin, MR Dweck, NR Evans, RAP Takx… - Circulation …, 2016 - Am Heart Assoc
Advances in atherosclerosis imaging technology and research have provided a range of
diagnostic tools to characterize high-risk plaque in vivo; however, these important vascular …

Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography …

A Tawakol, ZA Fayad, R Mogg, A Alon… - Journal of the American …, 2013 - jacc.org
Objectives: The study sought to test whether high-dose statin treatment would result in
greater reductions in plaque inflammation than low-dose statins, using fluorodeoxyglucose …

Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study …

AJV Mézquita, F Biavati, V Falk, H Alkadhi… - Nature Reviews …, 2023 - nature.com
The detection and characterization of coronary artery stenosis and atherosclerosis using
imaging tools are key for clinical decision-making in patients with known or suspected …

PET imaging of inflammation in atherosclerosis

JM Tarkin, FR Joshi, JHF Rudd - Nature Reviews Cardiology, 2014 - nature.com
PET imaging of atherosclerosis can quantify several in vivo pathological processes
occurring within the arterial system. 18F-fluorodeoxyglucose (FDG) is the most-commonly …