Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …

The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are
dramatically increasing access to the microbiome and identification of its links with disease …

Molecular networking is a tandem mass spectrometry (MS/MS) data organizational
approach that has been recently introduced in the drug discovery, metabolomics, and …

Sepsis is a potentially fatal condition caused by dysregulation of the body's immune
response to an infection. Sepsis-induced liver injury is considered a strong independent …

“Sola dosis facit venenum.” These words of Paracelsus,“the dose makes the poison”, can
lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance …

Small molecule tyrosine kinase inhibitors (TKIs) are widely used as anticancer drugs
approved by US FDA. However, the toxicities of TKIs to multiple organs have greatly limited …

Abstract Background Elexacaftor-Tezacaftor-Ivacaftor (ETI) therapy is showing promising
efficacy for treatment of cystic fibrosis (CF) and is becoming more widely available since …

Background Cystic fibrosis (CF) is a genetic disorder causing poor mucociliary clearance in
the airways and subsequent respiratory infection. The recently approved triple therapy …

Gut microbiota–host co-metabolites serve as essential mediators of communication between
the host and gut microbiota. They provide nutrient sources for host cells and regulate gut …