Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

Keratins make up the largest subgroup of intermediate filament proteins and represent the
most abundant proteins in epithelial cells. They exist as highly dynamic networks of …

Background Dysregulation of the epitranscriptome causes abnormal expression of
oncogenes in the tumorigenic process. Previous studies have shown that NAT10 can …

Intermediate filaments (IFs) are cytoskeletal polymers whose protein constituents are
encoded by a large family of differentially expressed genes. Owing in part to their properties …

Intermediate filaments (IFs) impart mechanical integrity to cells, yet IF mechanics are poorly
understood. It is assumed that IFs in cells are as stiff as hard α-keratin, F-actin, and …

Keratins make up the largest subgroup of intermediate filament (IF) proteins and form a
dynamic network of 10–12nm filaments, built from type I/type II heterodimers, in the …

Desmosomes are intercellular adhesion complexes that connect the intermediate filament
cytoskeletons of neighboring cells, and are essential for the mechanical integrity of …

Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form
the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate …

The ability to heal wounds is vital to all organisms. In mammalian tissues, alterations in
intermediate filament (IF) gene expression represent an early reaction of cells surviving …

The assembly and organization of the three major eukaryotic cytoskeleton proteins, actin,
microtubules, and intermediate filaments, are highly interdependent. Through evolution …