Publisher Summary This chapter summarizes recent information on the function of high-
mobility-group (HMG) proteins. Advances in this field were made primarily by elucidating the …

▪ Abstract Chromatin structure is now believed to be dynamic and intimately related with
cellular processes such as transcription. Over the past few years, high-resolution structures …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Nuclear receptors (NRs) are ligand‐inducible transcription factors that mediate complex
effects on development, differentiation and homeostasis. They regulate the transcription of …

Posttranslational modifications of histones are involved in regulation of chromatin structure
and gene activity. Whereas the modifications of the core histones H2A, H2B, H3, and H4 …

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …

The nature of the complexes of histones H1 and H5 and their globular domains (GH1 and
GH5) with DNA suggested two DNA‐binding sites which are likely to be the basis of the …

The high mobility group proteins 1 and 2 (HMG1/2) and histone B4 are major components of
chromatin within the nuclei assembled during the incubation of Xenopus sperm chromatin in …

Native bulk chromatin is characterized by regular arrays of nucleosomes with defined
internucleosomal distances. The nucleosome repeat length is not a constant but varies …