Human menopause is widely associated with impaired skeletal muscle quality and
significant metabolic dysfunction. These observations pose significant challenges to the …

Skeletal muscle contractile function is impaired in menopause and exercise may mitigate
this decline. We used the 4-vinylcyclohexene diepoxide (VCD) model of menopause to …

The loss of skeletal muscle strength mid-life in females is associated with the decline of
estrogen. Here, we questioned how estrogen deficiency might impact the overall skeletal …

Objective Menopause is associated with impaired skeletal muscle contractile function. The
temporal and mechanistic bases of this dysfunction are unknown. Using a mouse model of …

The abrupt cessation of ovarian hormone release is associated with declines in muscle
contractile function, yet the impact of gradual ovarian failure on muscle contractility across …

Estradiol and estrogen receptor α (ERα) have been shown to be important for the
maintenance of skeletal muscle strength in females; however, little is known about the roles …

Estradiol affects several properties of skeletal muscle in females including strength. Here,
we developed an approach to measure in vivo posttetanic twitch potentiation (PTP) of the …

Skeletal muscle mass and strength decline with age, which contributes to impaired balance
and reduced mobility, leading to falls. In fact, measures of muscle mass and strength are …

Objective Menopause is associated with impairments in muscle contractile function. The
temporal and mechanistic basis of this dysfunction are not known. Using a mouse model of …

Physiological Genomics continues to publish exciting research at the intersection of high
throughput 'omics technologies and physiology. In the past year, research findings in the …