Phthalates are a huge class of chemicals with a wide spectrum of industrial uses, from the
manufacture of plastics to food contact applications, children's toys, and medical devices …

Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …

Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …

Histone deacetylase 6 (HDAC6), a member of the HDAC family whose major substrate is α‐
tubulin, has become a target for drug development to treat cancer due to its major …

Abnormal epigenetic control is a common early event in tumour progression, and aberrant
acetylation in particular has been implicated in tumourigenesis. One of the most promising …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

Histone deacetylase (HDAC) 6 is a member of the class IIb HDAC family. This enzyme is
zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with …

Acetylation and deacetylation are counteracting, post-translational modifications that affect a
large number of histone and nonhistone proteins. The significance of histone acetylation in …