The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Despite improvement of antifungal therapies over the last 30 years, the phenomenon of
antifungal resistance is still of major concern in clinical practice. In the last 10 years the …

Fungal infection has become one of the leading causes of hospital-acquired infections with
high mortality rates. Furthermore, drug resistance is common for fungus-causing diseases …

Recent investigations have yielded both profound insights into the mechanisms required by
pathogenic fungi for virulence within the human host, as well as novel potential targets for …

The evolution of drug resistance in microbial pathogens provides a paradigm for
investigating evolutionary dynamics with important consequences for human health …

Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in
several cellular processes. The calcineurin signaling cascade is one of the major pathways …

Invasive fungal infections are a leading cause of mortality among immunocompromised
individuals. Treatment is notoriously difficult with the limited armamentarium of antifungal …

The frequency of severe systemic fungal diseases has increased in the last few decades.
The clinical use of antibacterial drugs, immunosuppressive agents after organ …

The survival of all organisms depends critically upon interactions with the environment,
mediated largely through the action of small molecules. Small molecules can provide the …

Mitogen-activated protein kinase (MAPK) cascades and the calcium–calcineurin pathway
control fundamental aspects of fungal growth, development and reproduction. Core …