Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

M Masoodi, A Gastaldelli, T Hyötyläinen… - Nature reviews …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

Y Geng, KN Faber, VE de Meijer, H Blokzijl… - Hepatology …, 2021 - Springer
Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …

Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease

L Castera, M Friedrich-Rust, R Loomba - Gastroenterology, 2019 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is estimated to afflict approximately 1 billion
individuals worldwide. In a subset of NAFLD patients, who have the progressive form of …

[PDF][PDF] Pathogenesis of nonalcoholic steatohepatitis: an overview

G Parthasarathy, X Revelo… - Hepatology …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases
characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected …

Past, present and future perspectives in nonalcoholic fatty liver disease

AJ Sanyal - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four
decades ago. However, the condition has become the centre of attention within hepatology …

Noninvasive biomarkers in NAFLD and NASH—current progress and future promise

VWS Wong, LA Adams, V de Lédinghen… - Nature reviews …, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult population and is
the most common chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH) is …

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers

E Vilar-Gomez, N Chalasani - Journal of hepatology, 2018 - Elsevier
The correct identification of patients at increased risk of non-alcoholic steatohepatitis
(NASH) and advanced fibrosis is a critical step in the assessment of non-alcoholic fatty liver …

Hypertension, diabetes, atherosclerosis and NASH: cause or consequence?

A Lonardo, F Nascimbeni, A Mantovani, G Targher - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of
chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD …

Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments

C Peng, AG Stewart, OL Woodman… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …