Introduction: Alzheimer's disease (AD) is a slow, irreversible, progressive, complex, and fatal
neurodegenerative disorder. Available pharmacological treatment, known for almost two …

Reduced middle cerebral artery blood velocity (MCAv) and flow pulsatility are contributors to
age-related cerebrovascular disease pathogenesis. It is unknown whether the rate of …

When exercising humans increase their oxygen uptake (V̇O2) 20-fold above rest the
numbers are staggering: Each minute the O2 transport system-lungs, cardiovascular, active …

Background Evidence suggests that the intake of blueberry (poly) phenols is associated with
improvements in vascular function and cognitive performance. Whether these cognitive …

The cerebral circulation responds differently to increases in mean arterial pressure (MAP),
compared to reductions in MAP. We tested the hypothesis that this directional sensitivity is …

High-intensity interval training (HIIE) may present unique challenges to the cerebrovascular
system in individuals post-stroke. We hypothesized lower middle cerebral artery blood …

New Findings What is the central question of the study? What is the reliability of middle
cerebral artery velocity cerebrovascular reactivity (CVR) when using traditional and novel …

Purpose: Ageing is associated with impaired cerebral blood flow (CBF) and increased risk of
cerebrovascular disease. Acute increases in CBF during exercise may initiate improvements …

Despite its necessity for understanding healthy brain aging, the influence of exercise
intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized …

High-intensity interval exercise (HIIT) is performed widely. However, there is a gap in
knowledge regarding the acute cerebrovascular response to low-volume HIIT. Our objective …