Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Introduction: Human cancers are genetically and epigenetically heterogeneous and have
the capacity to commandeer a variety of cellular processes to aid in their survival, growth …

BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that regulate the
expression of approximately 60% of all human genes. They play important roles in …

Abstract Astrocyte elevated gene-1 (AEG-1) was initially identified as an HIV-1-and tumor
necrosis factor α (TNF-α)–inducible transcript in primary human fetal astrocytes by a rapid …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

Background Bone marrow derived mesenchymal stem cells (BM-MSCs) are used
extensively in transplantation but their use is associated with many problems including low …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …

IL-24 is a member of the IL-10 family of cytokines. In this study, we investigated IL-24
expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD), and …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …