[HTML][HTML] Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
RAS-targeted therapies: is the undruggable drugged?
AR Moore, SC Rosenberg, F McCormick… - Nature reviews Drug …, 2020 - nature.com
Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
[HTML][HTML] Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
[PDF][PDF] Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress
Malignant transformation can result in melanoma cells that resemble different stages of their
embryonic development. Our gene expression analysis of human melanoma cell lines and …
embryonic development. Our gene expression analysis of human melanoma cell lines and …
[HTML][HTML] Cutaneous melanoma: From pathogenesis to therapy
GC Leonardi, L Falzone, R Salemi… - International …, 2018 - spandidos-publications.com
In less than 10 years, melanoma treatment has been revolutionized with the approval of
tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to …
tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to …
Clinical cancer genomic profiling
D Chakravarty, DB Solit - Nature Reviews Genetics, 2021 - nature.com
Technological innovation and rapid reduction in sequencing costs have enabled the
genomic profiling of hundreds of cancer-associated genes as a component of routine cancer …
genomic profiling of hundreds of cancer-associated genes as a component of routine cancer …
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
Understanding the profile of oncogene and tumor suppressor gene mutations with their
interactions and impact on the prognosis of multiple myeloma (MM) can improve the …
interactions and impact on the prognosis of multiple myeloma (MM) can improve the …
[HTML][HTML] Genomic classification of cutaneous melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
High-throughput functional genomics using CRISPR–Cas9
Forward genetic screens are powerful tools for the discovery and functional annotation of
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
CRISPR-Cas9–based genetic screens are a powerful new tool in biology. By simply altering
the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target different …
the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target different …