An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking

W Yang, Q Feng, Z Peng, G Wang - European Journal of Medicinal …, 2022 - Elsevier
Urease is a kind of enzyme which could be found in various bacteria, fungi, plants, and
algae, which can quickly catalyze the hydrolysis of urea into ammonia and carbon dioxide …

Evaluating anti-coronavirus activity of some phosphoramides and their influencing inhibitory factors using molecular docking, DFT, QSAR, and NCI-RDG studies

K Gholivand, F Mohammadpanah, M Pooyan… - Journal of Molecular …, 2022 - Elsevier
The recent prevalence of coronavirus disease in 2019 (COVID-19) has triggered
widespread global health concerns. Antiviral drugs based on phosphoramides have …

In vitro cytotoxicity evaluation of organotin (IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies

M Pooyan, Z Shariatinia, F Mohammadpanah… - Journal of Molecular …, 2023 - Elsevier
Considering the valuable position of organotins and the biotic role of phosphorus
compounds in biological processes, in this research work, we investigated and introduced a …

Urease Inhibition and Structure‐Activity Relationship Study of Thiazolidinone‐, Triazole‐, and Benzothiazole‐Based Heterocyclic Derivatives: A Focus Review

R Singh, P Kumar, M Devi, J Sindhu, A Kumar… - …, 2023 - Wiley Online Library
Urease has a long and distinguished history in the development of enzymology since it was
the first enzyme crystallized by Sumner in 1926. The present review article is focused on the …

Primary Amination of Ar2P(O)–H with (NH4)2CO3 as an Ammonia Source under Simple and Mild Conditions and Its Extension to the Construction of Various P–N …

Y Tan, YP Han, Y Zhang, HY Zhang… - The Journal of …, 2022 - ACS Publications
A facile and efficient method for the synthesis of primary phosphinamides from Ar2P (O)–H
reagents with stable and readily available ammonium carbonate as an ammonia source is …

An acetohydroxamate-coordinated oxidovanadium (V) complex derived from pyridinohydrazone ligand with urease inhibitory activity

Y Li, L Xu, M Duan, J Wu, Y Wang, K Dong… - Inorganic Chemistry …, 2019 - Elsevier
A new acetohydroxamate coordinated oxidovanadium (V) complex derived from the
pyridinohydrazone ligand 2′-(2-hydroxy-4-methoxybenzylidene) nicotinohydrazide (H 2 L) …

Inactivation of Jack Bean Urease by Nitidine Chloride from Zanthoxylum nitidum: Elucidation of Inhibitory Efficacy, Kinetics and Mechanism

Q Lu, D Tan, Y Xu, M Liu, Y He, C Li - Journal of Agricultural and …, 2021 - ACS Publications
Urease is a metalloenzyme that catalyzes the hydrolysis of urea into ammonia and carbon
dioxide, which has a negative impact on human health and agriculture. In this study, the …

Fabrication of multinuclear copper cluster-based coordination polymers as urease inhibitors

WL Duan, KT Wang, F Yan, J Luan - Dalton Transactions, 2024 - pubs.rsc.org
This study focused on the design and synthesis of two Cu-based coordination
polymers,[Cu2 (4-dpye)(5-HSIP)(μ3-O)(H2O) 2]· 3H2O (Cu-CP-1) and [Cu (4-dpye) 0.5 …

Anti-cancer activity of new phosphoramide-functionalized graphene oxides: an experimental and theoretical evaluation

K Gholivand, M Faraghi, M Pooyan… - Current Medicinal …, 2023 - ingentaconnect.com
Background: Graphene oxide (GO)-based systems are among the drug delivery systems
and have drawn a lot of interest in the field of medicine. Methods: In this work, two novel …

Synthesis and biological evaluation of triazolones/oxadiazolones as novel urease inhibitors

YN Wang, SY Li, LC Yuan, SF Bu, Y Zeng… - Bioorganic & Medicinal …, 2024 - Elsevier
Urease is the main virulence factor of infectious gastritis and gastric ulcers. Urease inhibitors
are regarded as the first choice for the treatment of such diseases. Based on the triazolone …