High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Recent advances in glycoproteomic analysis by mass spectrometry

S Suttapitugsakul, F Sun, R Wu - Analytical chemistry, 2019 - ACS Publications
Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx

M Mounir, M Lucchetta, TC Silva, C Olsen… - PLoS computational …, 2019 - journals.plos.org
The advent of Next-Generation Sequencing (NGS) technologies has opened new
perspectives in deciphering the genetic mechanisms underlying complex diseases …

Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples

AL Marie, S Ray, AR Ivanov - Nature Communications, 2023 - nature.com
Alterations of protein glycosylation can serve as sensitive and specific disease biomarkers.
Labeling procedures for improved separation and detectability of oligosaccharides have …

Recent advances in glycoinformatic platforms for glycomics and glycoproteomics

JL Abrahams, G Taherzadeh, G Jarvas… - Current opinion in …, 2020 - Elsevier
Highlights•Recent advancements in glycoinformatics tools to support analysis of glycan and
glycopeptide data sets are summarised.•Review summarises the growth of machine …

Cancer cell glycocalyx and its significance in cancer progression

H Kang, Q Wu, A Sun, X Liu, Y Fan, X Deng - International journal of …, 2018 - mdpi.com
Cancer is a malignant tumor that threatens the health of human beings, and has become the
leading cause of death in urban and rural residents in China. The glycocalyx is a layer of …

Ultrasensitive optical detection and elimination of residual microtumors with a postoperative implantable hydrogel sensor for preventing cancer recurrence

S Geng, P Guo, J Wang, Y Zhang, Y Shi, X Li… - Advanced …, 2024 - Wiley Online Library
In vivo optical imaging of trace biomarkers in residual microtumors holds significant promise
for cancer prognosis but poses a formidable challenge. Here, a novel hydrogel sensor is …

High-sensitivity glycan profiling of blood-derived immunoglobulin G, plasma, and extracellular vesicle isolates with capillary zone electrophoresis-mass spectrometry

AL Marie, S Ray, S Lu, J Jones, I Ghiran… - Analytical …, 2021 - ACS Publications
We developed a highly sensitive method for profiling of N-glycans released from proteins
based on capillary zone electrophoresis coupled to electrospray ionization mass …

Clinical application of quantitative glycomics

W Peng, J Zhao, X Dong, A Banazadeh… - Expert review of …, 2018 - Taylor & Francis
Introduction: Aberrant glycosylation has been associated with many diseases. Decades of
research activities have reported many reliable glycan biomarkers of different diseases …

Identification and validation of IgG N-glycosylation biomarkers of esophageal carcinoma

H Pan, Z Wu, H Zhang, J Zhang, Y Liu, Z Li… - Frontiers in …, 2023 - frontiersin.org
Introduction Altered Immunoglobulin G (IgG) N-glycosylation is associated with aging,
inflammation, and diseases status, while its effect on esophageal squamous cell carcinoma …