The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

Concomitant with our increasing knowledge of the structure and biological role of nucleic
acids is the interest in the development of small molecules that can regulate DNA and RNA …

Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far
outpaces the research on the structure and functional interactions of these RNA gene …

Remarkable findings have cemented the central dogma of biology, where the transfer of
genetic information from a sequence of nucleotides in DNA to a string of amino acids in …

Recombinant proteins are important therapeutics due to potent, highly specific, and nontoxic
actions in vivo. However, they are expensive medicines to manufacture, chemically …

In recent years, there has been dramatic growth in the study of RNA. RNA has gone from
being known as an intermediate in the central dogma of molecular biology to a molecule …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …

Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral
RNA sites, including the HIV-1 Rev response element (RRE). The design, synthesis, and …

Structure-based drug design is now well-established for proteins as a key first step in the
lengthy process of developing new drugs. In many ways, RNA may be a better target to treat …