Cell-mediated immune response to human papillomavirus infection

M Scott, M Nakagawa, AB Moscicki - Clinical Diagnostic …, 2001 - Am Soc Microbiol
Acquisition of human papillomavirus (HPV) results in an infection of variable duration which
may or may not be associated with clinically apparent lesions. Lesions caused by skintropic …

The role of inflammation in HPV carcinogenesis

E Boccardo, AP Lepique, LL Villa - Carcinogenesis, 2010 - academic.oup.com
The role of inflammation in human papillomavirus (HPV) infection and disease is complex
since it involves responses capable of preventing initial infections, clearing those ongoing …

Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus

DJ Sharkey, KP Tremellen, MJ Jasper… - The Journal of …, 2012 - journals.aai.org
In mice, seminal fluid elicits an inflammation-like response in the female genital tract that
activates immune adaptations to advance the likelihood of conception and pregnancy. In this …

Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice

E Tartour, F Fossiez, I Joyeux, A Galinha, A Gey… - Cancer research, 1999 - AACR
Interleukin (IL) 17 is a proinflammatory cytokine secreted mainly by activated human
memory CD4 T cells that induces IL-6, IL-8, and nitric oxide. Because IL-6 and IL-8 have …

Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells

DJ Sharkey, AM Macpherson… - Molecular human …, 2007 - academic.oup.com
Exposure to semen elicits an inflammatory response in the female reproductive tract of
rodents and other animals. The nature and regulation of any similar response in humans is …

Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types

H Zur Hausen - Human pathogenic papillomaviruses, 1994 - Springer
Less than 10 years after publication of the hypothesis of a papillomavirus etiology of cancer
of the cervix (zur Hausen 1975, 1976, 1977), the DNAs of the first cervical cancer-associated …

TGF-β mediates proinflammatory seminal fluid signaling in human cervical epithelial cells

DJ Sharkey, AM Macpherson, KP Tremellen… - The Journal of …, 2012 - journals.aai.org
The cervix is central to the female genital tract immune response to pathogens and foreign
male Ags introduced at coitus. Seminal fluid profoundly influences cervical immune function …

Cytokine networks and the regulation of uterine function in pregnancy and parturition

NM Orsi, RM Tribe - Journal of neuroendocrinology, 2008 - Wiley Online Library
Complex cytokine networks play an important role in a wide range of reproductive and
pregnancy related processes. Here, we review the current knowledge concerning the impact …

Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells

RN Fichorova, DJ Anderson - Biology of reproduction, 1999 - academic.oup.com
We have recently generated human papillomavirus (HPV) 16/E6E7 immortalized epithelial
cell lines from the human vagina, ectocervix, and endocervix to use in studies on the role of …

Human papillomavirus infections: epidemiology, pathogenesis, and host immune response

SK Tyring - Journal of the American Academy of Dermatology, 2000 - Elsevier
Human papillomaviruses (HPVs) are ubiquitous and often cause lesions on the skin that
come to the attention of the dermatologist. Skin lesions, or warts, often occur on the hands or …