Plakoglobin (also known as?-catenin) is a member of the Armadillo family of proteins and a
paralog of β-catenin. Plakoglobin is a component of both the adherens junctions and …

Intercalated discs (ICDs) are highly orchestrated structures that connect neighboring
cardiomyocytes in the heart. Three major complexes are distinguished in ICD: desmosome …

Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer's
disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from …

Endometrial cancer is the most common gynaecological malignancy in developed nations,
and its prevalence is rising as women defer or decide not to have children and as obesity …

Progranulin is a growth factor with pro-tumorigenic activity. We recently demonstrated that in
mesothelioma, progranulin regulates cell migration, invasion, adhesion, and in vivo tumor …

Background Mesothelioma is an aggressive disease with limited therapeutic options. The
growth factor progranulin plays a critical role in several cancer models, where it regulates …

Viruses are obligate parasites dependent on host cells for survival. Viral infection of a cell
activates a panel of pattern recognition receptors that mediate antiviral host responses to …

Invasive micropapillary carcinoma of the breast (IMPC) is a rare subtype of breast cancer
that has a high frequency of lymph node (LN) involvement and metastasis to distant organs …

Background KRAS mutations are the most frequent oncogenic aberration in lung
adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence …

Cellular proliferation, differentiation, and morphogenesis are shaped by multiple signaling
cascades, and their dysregulation plays an integral role in cancer progression. Three …