[HTML][HTML] Role of fibrinolytic enzymes in anti-thrombosis therapy

F Altaf, S Wu, V Kasim - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Thrombosis, a major cause of deaths in this modern era responsible for 31% of all global
deaths reported by WHO in 2017, is due to the aggregation of fibrin in blood vessels which …

[HTML][HTML] Microbial therapeutic enzymes: A promising area of biopharmaceuticals

M Vachher, A Sen, R Kapila, A Nigam - Current Research in Biotechnology, 2021 - Elsevier
Biopharmaceuticals is a rapidly emerging field that explores and employs biological
organisms and their products for therapeutic applications. Enzymes are remarkable …

[HTML][HTML] Thrombolytic enzymes of microbial origin: a review

D Diwan, Z Usmani, M Sharma, JW Nelson… - International journal of …, 2021 - mdpi.com
Enzyme therapies are attracting significant attention as thrombolytic drugs during the current
scenario owing to their great affinity, specificity, catalytic activity, and stability. Among various …

Use of exogenous enzymes in human therapy: approved drugs and potential applications

P Cioni, E Gabellieri, B Campanini… - Current Medicinal …, 2022 - ingentaconnect.com
The development of safe and efficacious enzyme-based human therapies has increased
greatly in the last decades, thanks to remarkable advances in the understanding of the …

Efficacy and safety of a bolus of half-dose R-SAK prior to primary PCI in ST-elevation myocardial infarction: Rationale and design of the optima-6 trial

C Li, JW Eikelboom, Z Zhong, X Zhang, K Liu… - American Heart …, 2023 - Elsevier
Background Time to reperfusion is the key to the treatment of patients with ST-elevation
myocardial infarction (STEMI). It is uncertain whether adjunctive thrombolytic therapy …

[HTML][HTML] CcpA Regulates Staphylococcus aureus Biofilm Formation through Direct Repression of Staphylokinase Expression

M Zheng, K Zhu, H Peng, W Shang, Y Zhao, S Lu… - Antibiotics, 2022 - mdpi.com
Staphylococcus aureus represents a notorious opportunistic pathogen causing various
infections in biofilm nature, imposing remarkable therapeutic challenges worldwide. The …

Recent trends in targeted delivery of smart nanocarrier-based microbial enzymes for therapeutic applications

N Jangra, A Kawatra, B Datten, S Gupta, P Gulati - Drug Discovery Today, 2024 - Elsevier
Smart carrier-based immobilization has widened the use of enzymes for the treatment of
several disorders. Large surface areas, tunable morphology, and surface modification ability …

Engineered Microrobots for Targeted Delivery of Bacterial Outer Membrane Vesicles (OMV) in Thrombus Therapy

Z Cong, Y Li, L Xie, Q Chen, M Tang, P Thongpon… - Small, 2024 - Wiley Online Library
In the realm of thrombosis treatment, bioengineered outer membrane vesicles (OMVs) offer
a novel and promising approach, as they have rich content of bacterial‐derived components …

Platelet Membrane-Coated r-SAK Improves Thrombolytic Efficacy by Targeting Thrombus

R Hua, M Li, Q Lin, M Dong, X Gong, Z Lin… - … Applied Materials & …, 2024 - ACS Publications
Thrombolytic therapy is one of the most effective treatments for thrombus dissolution and
recanalization of blocked vessels in thrombotic diseases. However, the application of the …

Macroalgae: Marine players in vaccinology

E Trujillo, E Monreal-Escalante, A Ramos-Vega… - Algal Research, 2024 - Elsevier
Although seaweeds have been used for decades as food, medicinal plants, and nutritional
supplements, their use as a vaccine production and delivery platform has been barely …