Here, we provide an update of our review on homeobox genes that we wrote together with
Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have …

Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

We have cloned and characterized two novel DNA binding proteins designated RAV1 and
RAV2 from Arabidopsis thaliana. RAV1 and RAV2 contain two distinct amino acid sequence …

Pax6 is a highly conserved transcription factor among vertebrates and is important in various
developmental processes in the central nervous system (CNS), including patterning of the …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

▪ Abstract Pax-6 is a member of the Pax gene class and encodes a protein containing a
paired domain and a homeodomain. The molecular characterization of Pax-6 genes from …

Understanding brain development remains a major challenge at the heart of understanding
what makes us human. The neocortex, in evolutionary terms the newest part of the cerebral …

PAX proteins function as transcription factors and play an essential role in organogenesis
during embryonic development in regulating cell proliferation and self-renewal, resistance to …

Pax6 is a transcription factor essential for the development of tissues including the eyes,
central nervous system and endocrine glands of vertebrates and invertebrates. It regulates …

The DNA-binding transcription factor PAX6 was cloned 25 years ago by multiple teams
pursuing identification of human and mouse eye disease causing genes, cloning vertebrate …