The B7: CD28 family and friends: Unraveling coinhibitory interactions
KP Burke, A Chaudhri, GJ Freeman, AH Sharpe - Immunity, 2024 - cell.com
Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …
Regulatory mechanisms of PD-1/PD-L1 in cancers
X Lin, K Kang, P Chen, Z Zeng, G Li, W Xiong, M Yi… - Molecular Cancer, 2024 - Springer
Immune evasion contributes to cancer growth and progression. Cancer cells have the ability
to activate different immune checkpoint pathways that harbor immunosuppressive functions …
to activate different immune checkpoint pathways that harbor immunosuppressive functions …
T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle
WP Lin, H Li, ZJ Sun - Ebiomedicine, 2024 - thelancet.com
Immune therapies represented by immune checkpoint blockade (ICB) have significantly
transformed cancer treatment. However, the effectiveness of these treatments depends on …
transformed cancer treatment. However, the effectiveness of these treatments depends on …
Local Enrichment with Convergence of Enriched T-Cell Clones Are Hallmarks of Effective Peptide Vaccination against B16 Melanoma
AV Izosimova, AV Shabalkina, MY Myshkin… - Vaccines, 2024 - mdpi.com
Background: Some peptide anticancer vaccines elicit a strong T-cell memory response but
fail to suppress tumor growth. To gain insight into tumor resistance, we compared two …
fail to suppress tumor growth. To gain insight into tumor resistance, we compared two …
[HTML][HTML] A Journey through the Minefield of the Discovery and Characterization of Latency-Related RNA/Latency-Associated Transcript
H Ghiasi - Viruses, 2024 - pmc.ncbi.nlm.nih.gov
Scientific knowledge evolves in small steps, with occasional backsteps to correct
inaccuracies, all occurring within a competitive environment. This perspective for the first …
inaccuracies, all occurring within a competitive environment. This perspective for the first …
Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD mice
T cells primarily drive the autoimmune destruction of pancreatic beta cells in Type 1 diabetes
(T1D). However, the profound yet uncharacterized diversity of the T cell populations in vivo …
(T1D). However, the profound yet uncharacterized diversity of the T cell populations in vivo …
UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors
HC Chen, HH Wang, LA Kohn, D Sailer, S Zhang… - bioRxiv, 2024 - biorxiv.org
Summary Type 1 Diabetes Mellitus (T1D) is an autoimmune disease caused by unremitting
immune attack on pancreas insulin-producing beta cells. Persistence of the autoimmune …
immune attack on pancreas insulin-producing beta cells. Persistence of the autoimmune …
Polyfunctional IL-21+ IFNg+ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy
N Huang, J Ortega, K Kimbrell, J Lee, LN Scott… - bioRxiv, 2024 - biorxiv.org
Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, but their use is
limited by the development of autoimmunity in healthy tissues as a side effect of treatment …
limited by the development of autoimmunity in healthy tissues as a side effect of treatment …
Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD mice
T cells primarily drive the autoimmune destruction of pancreatic beta cells in Type 1 diabetes
(T1D). However, the profound yet uncharacterized diversity of the T cell populations in vivo …
(T1D). However, the profound yet uncharacterized diversity of the T cell populations in vivo …